Drug interactions
Fenofibrate + Pitavastatin
Severity: Moderate
Fenofibrate and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with a statin raises the chance of myopathy and rhabdomyolysis compared with either drug alone. Fenofibrate carries a lower risk than gemfibrozil because it does not markedly raise statin concentrations, but additive muscle toxicity is still possible, especially with renal impairment, older age or hypothyroidism.
What this interaction means in plain words
Fenofibrate and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.
Why it happens
Additive myotoxic effects of both drug classes, with little pharmacokinetic interaction for fenofibrate and pitavastatin.
What to do
If the combination is needed for mixed dyslipidemia, use the lowest effective doses and counsel the patient to report unexplained muscle pain or weakness. Check CK if symptoms develop and stop therapy if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Pitavastatin?
MediHelp rates the interaction as moderate. Fenofibrate and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with a statin raises the chance of myopathy and rhabdomyolysis compared with either drug alone. Fenofibrate carries a lower risk than gemfibrozil because it does not markedly raise statin concentrations, but additive muscle toxicity is still possible, especially with renal impairment, older age or hypothyroidism.
How serious is the interaction between Fenofibrate and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is needed for mixed dyslipidemia, use the lowest effective doses and counsel the patient to report unexplained muscle pain or weakness. Check CK if symptoms develop and stop therapy if myopathy is suspected.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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