Drug interactions
Fenofibrate + Tenofovir disoproxil
Severity: Minor
Fenofibrate and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established pharmacokinetic interaction between these drugs. Fenofibrate can slightly raise serum creatinine, which may complicate assessment of tenofovir-related renal effects. Fenofibrate also carries its own myopathy risk, not clearly increased by tenofovir.
What this interaction means in plain words
Fenofibrate and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; fenofibrate-related creatinine elevation may confound renal monitoring.
What to do
Monitor creatinine and phosphate periodically and interpret small creatinine rises with the fenofibrate effect in mind. Report muscle pain or weakness promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Fenofibrate and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established pharmacokinetic interaction between these drugs. Fenofibrate can slightly raise serum creatinine, which may complicate assessment of tenofovir-related renal effects. Fenofibrate also carries its own myopathy risk, not clearly increased by tenofovir.
How serious is the interaction between Fenofibrate and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and phosphate periodically and interpret small creatinine rises with the fenofibrate effect in mind. Report muscle pain or weakness promptly.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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