Drug interactions
Fenofibric acid + Fluvastatin
Severity: Moderate
Fenofibric acid and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with a statin raises the chance of skeletal muscle toxicity, from myalgia to rhabdomyolysis. Fluvastatin is metabolized mainly by CYP2C9 and has less pharmacokinetic overlap with fenofibric acid than other statins, so the risk is mostly additive muscle toxicity.
What this interaction means in plain words
Fenofibric acid and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity of the two lipid-lowering classes, with little pharmacokinetic interaction.
What to do
Use the combination only when the added triglyceride lowering is clearly needed, starting with the lowest effective doses. Counsel patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Fluvastatin?
MediHelp rates the interaction as moderate. Fenofibric acid and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with a statin raises the chance of skeletal muscle toxicity, from myalgia to rhabdomyolysis. Fluvastatin is metabolized mainly by CYP2C9 and has less pharmacokinetic overlap with fenofibric acid than other statins, so the risk is mostly additive muscle toxicity.
How serious is the interaction between Fenofibric acid and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when the added triglyceride lowering is clearly needed, starting with the lowest effective doses. Counsel patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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