Drug interactions
Fenofibric acid + Gliclazide
Severity: Minor
Fenofibric acid and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid is highly protein bound and fibrates may modestly improve insulin sensitivity. Together with gliclazide this could lead to a greater glucose-lowering effect and occasional hypoglycemia. The clinical significance is limited and documentation is sparse.
What this interaction means in plain words
Fenofibric acid and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding sites and additive improvement in glycemic control; the mechanism is not firmly established.
What to do
Monitor blood glucose when fenofibric acid is started or stopped in a patient on gliclazide. Reduce the gliclazide dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Gliclazide?
MediHelp rates the interaction as minor. Fenofibric acid and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibric acid is highly protein bound and fibrates may modestly improve insulin sensitivity. Together with gliclazide this could lead to a greater glucose-lowering effect and occasional hypoglycemia. The clinical significance is limited and documentation is sparse.
How serious is the interaction between Fenofibric acid and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibric acid is started or stopped in a patient on gliclazide. Reduce the gliclazide dose only if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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