Drug interactions
Fenofibric acid + Glipizide-metformin
Severity: Minor
Fenofibric acid and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid is highly protein bound and may modestly raise free glipizide levels, so hypoglycemia is possible, especially with low albumin. Fibrates may also change insulin sensitivity and glucose levels. The clinical effect is generally small and manageable.
What this interaction means in plain words
Fenofibric acid and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible displacement of glipizide from plasma protein binding sites, plus additive effects on glucose handling that are not well characterized.
What to do
Monitor blood glucose when fenofibric acid is started or stopped, particularly in patients with hypoalbuminemia. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Glipizide-metformin?
MediHelp rates the interaction as minor. Fenofibric acid and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibric acid is highly protein bound and may modestly raise free glipizide levels, so hypoglycemia is possible, especially with low albumin. Fibrates may also change insulin sensitivity and glucose levels. The clinical effect is generally small and manageable.
How serious is the interaction between Fenofibric acid and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibric acid is started or stopped, particularly in patients with hypoalbuminemia. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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