Drug interactions
Fenofibric acid + Larotrectinib
Severity: Minor
Fenofibric acid and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity at best, and fenofibric acid does not depend on CYP3A4 for clearance. A meaningful interaction is not expected.
What this interaction means in plain words
Fenofibric acid and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition affecting a minor elimination pathway of fenofibric acid.
What to do
No action is needed beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Fenofibric acid with Larotrectinib?
MediHelp rates the interaction as minor. Fenofibric acid and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity at best, and fenofibric acid does not depend on CYP3A4 for clearance. A meaningful interaction is not expected.
How serious is the interaction between Fenofibric acid and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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