Drug interactions
Fenofibric acid + Mavacamten
Severity: Moderate
Fenofibric acid and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized largely by CYP2C19 with a contribution from CYP3A4, and its exposure rises with CYP2C19 inhibitors. Fenofibric acid shows only weak CYP2C19 inhibition in vitro, so a clinically meaningful rise in mavacamten levels is uncertain, though it could worsen reduction in ejection fraction.
What this interaction means in plain words
Fenofibric acid and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP2C19 by fenofibric acid reducing mavacamten clearance.
What to do
Assess left ventricular ejection fraction and clinical status when fenofibric acid is started or stopped, following the mavacamten echocardiographic monitoring schedule. Reduce the mavacamten dose if ejection fraction falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Fenofibric acid with Mavacamten?
MediHelp rates the interaction as moderate. Fenofibric acid and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized largely by CYP2C19 with a contribution from CYP3A4, and its exposure rises with CYP2C19 inhibitors. Fenofibric acid shows only weak CYP2C19 inhibition in vitro, so a clinically meaningful rise in mavacamten levels is uncertain, though it could worsen reduction in ejection fraction.
How serious is the interaction between Fenofibric acid and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular ejection fraction and clinical status when fenofibric acid is started or stopped, following the mavacamten echocardiographic monitoring schedule. Reduce the mavacamten dose if ejection fraction falls.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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