Drug interactions
Fesoterodine + Prochlorperazine
Severity: Moderate
Fesoterodine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so use together can increase dry mouth, constipation, urinary retention, blurred vision and cognitive effects. Reduced gastrointestinal motility may also alter oral phenothiazine absorption.
What this interaction means in plain words
Fesoterodine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible slowed gastrointestinal transit.
What to do
Monitor for anticholinergic adverse effects and confusion, especially in elderly patients. Consider an alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Prochlorperazine?
MediHelp rates the interaction as moderate. Fesoterodine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so use together can increase dry mouth, constipation, urinary retention, blurred vision and cognitive effects. Reduced gastrointestinal motility may also alter oral phenothiazine absorption.
How serious is the interaction between Fesoterodine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and confusion, especially in elderly patients. Consider an alternative if symptoms develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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