Drug interactions
Fexofenadine + Levetiracetam
Severity: Minor
Fexofenadine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam commonly causes somnolence and fatigue, while fexofenadine rarely does. Additive sedation is possible but likely minor.
What this interaction means in plain words
Fexofenadine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Levetiracetam belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; no pharmacokinetic interaction is established.
What to do
No routine adjustment is needed. Advise patients to report increased drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Levetiracetam
Frequently asked questions
Can I take Fexofenadine with Levetiracetam?
MediHelp rates the interaction as minor. Fexofenadine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levetiracetam commonly causes somnolence and fatigue, while fexofenadine rarely does. Additive sedation is possible but likely minor.
How serious is the interaction between Fexofenadine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Advise patients to report increased drowsiness.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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