Drug interactions
Fexofenadine + Neratinib
Severity: Minor
Fexofenadine and Neratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib inhibits P-glycoprotein and may increase systemic exposure to fexofenadine. Fexofenadine tolerates higher levels well, so significant toxicity is unlikely.
What this interaction means in plain words
Fexofenadine and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Neratinib belongs to Oncology.
Why it happens
Neratinib inhibits P-gp-mediated efflux of fexofenadine, increasing absorption.
What to do
No empiric change is needed; watch for antihistamine adverse effects and lower the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Fexofenadine with Neratinib?
MediHelp rates the interaction as minor. Fexofenadine and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Neratinib inhibits P-glycoprotein and may increase systemic exposure to fexofenadine. Fexofenadine tolerates higher levels well, so significant toxicity is unlikely.
How serious is the interaction between Fexofenadine and Neratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric change is needed; watch for antihistamine adverse effects and lower the dose if they occur.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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