Drug interactions
Fexofenadine + Nicardipine
Severity: Minor
Fexofenadine and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can inhibit P-glycoprotein, which transports fexofenadine out of cells and back into the gut lumen. Fexofenadine levels could rise modestly, but this is unlikely to be clinically important because of fexofenadine's wide therapeutic margin.
What this interaction means in plain words
Fexofenadine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by nicardipine, increasing fexofenadine absorption.
What to do
No routine action is needed; monitor for increased antihistamine adverse effects only if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Nicardipine
Frequently asked questions
Can I take Fexofenadine with Nicardipine?
MediHelp rates the interaction as minor. Fexofenadine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine can inhibit P-glycoprotein, which transports fexofenadine out of cells and back into the gut lumen. Fexofenadine levels could rise modestly, but this is unlikely to be clinically important because of fexofenadine's wide therapeutic margin.
How serious is the interaction between Fexofenadine and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for increased antihistamine adverse effects only if symptoms appear.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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