Drug interactions
Fexofenadine + Quinidine
Severity: Minor
Fexofenadine and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and can raise fexofenadine concentrations. The increase is generally not clinically significant given fexofenadine's wide safety margin.
What this interaction means in plain words
Fexofenadine and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein mediated efflux and renal secretion of fexofenadine by quinidine.
What to do
No dose adjustment is usually needed. Monitor for antihistamine adverse effects if quinidine is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Fexofenadine with Quinidine?
MediHelp rates the interaction as minor. Fexofenadine and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein and can raise fexofenadine concentrations. The increase is generally not clinically significant given fexofenadine's wide safety margin.
How serious is the interaction between Fexofenadine and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for antihistamine adverse effects if quinidine is used.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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