Drug interactions
Fexofenadine + Tranylcypromine
Severity: Minor
Fexofenadine and Tranylcypromine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors are reported to intensify and prolong anticholinergic and sedative antihistamine effects. Fexofenadine has negligible anticholinergic and sedative activity, so a clinically relevant interaction is unlikely.
What this interaction means in plain words
Fexofenadine and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Theoretical additive CNS and anticholinergic effects; fexofenadine is minimally metabolized and not sedating.
What to do
No dose adjustment is needed. Ask the patient to report unusual drowsiness or anticholinergic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Fexofenadine with Tranylcypromine?
MediHelp rates the interaction as minor. Fexofenadine and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors are reported to intensify and prolong anticholinergic and sedative antihistamine effects. Fexofenadine has negligible anticholinergic and sedative activity, so a clinically relevant interaction is unlikely.
How serious is the interaction between Fexofenadine and Tranylcypromine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Ask the patient to report unusual drowsiness or anticholinergic symptoms.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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