Drug interactions
Fexofenadine + Verapamil
Severity: Minor
Fexofenadine and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a P-glycoprotein inhibitor and has been shown to increase fexofenadine plasma concentrations. The increase is generally modest and fexofenadine is well tolerated, so clinical consequences are usually limited.
What this interaction means in plain words
Fexofenadine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of fexofenadine by verapamil, increasing its absorption.
What to do
No dose adjustment is usually needed; monitor for sedation or other antihistamine adverse effects if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Fexofenadine with Verapamil?
MediHelp rates the interaction as minor. Fexofenadine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil is a P-glycoprotein inhibitor and has been shown to increase fexofenadine plasma concentrations. The increase is generally modest and fexofenadine is well tolerated, so clinical consequences are usually limited.
How serious is the interaction between Fexofenadine and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for sedation or other antihistamine adverse effects if symptoms appear.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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