Drug interactions
Finasteride + Secobarbital
Severity: Minor
Finasteride and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital, like other barbiturates, induces CYP3A4 and may reduce finasteride concentrations. The clinical impact is expected to be small given finasteride's wide margin.
What this interaction means in plain words
Finasteride and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finasteride belongs to Genitourinary; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated CYP3A4 induction increases finasteride clearance.
What to do
No routine adjustment is needed. Review therapeutic response if barbiturate use is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Finasteride with Secobarbital?
MediHelp rates the interaction as minor. Finasteride and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital, like other barbiturates, induces CYP3A4 and may reduce finasteride concentrations. The clinical impact is expected to be small given finasteride's wide margin.
How serious is the interaction between Finasteride and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Review therapeutic response if barbiturate use is prolonged.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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