Drug interactions
Finerenone + Fluoxetine
Severity: Moderate
Finerenone and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is metabolized mainly by CYP3A4, and weak inhibition by fluoxetine may modestly increase its exposure. This can raise the risk of hyperkalemia and reduced kidney function.
What this interaction means in plain words
Finerenone and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by fluoxetine reduces finerenone clearance.
What to do
Check serum potassium and renal function when starting or changing either drug. Adjust the finerenone dose if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Fluoxetine?
MediHelp rates the interaction as moderate. Finerenone and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Finerenone is metabolized mainly by CYP3A4, and weak inhibition by fluoxetine may modestly increase its exposure. This can raise the risk of hyperkalemia and reduced kidney function.
How serious is the interaction between Finerenone and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting or changing either drug. Adjust the finerenone dose if potassium rises.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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