Drug interactions
Finerenone + Glyburide
Severity: Minor
Finerenone and Glyburide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide is described as a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This may raise the risk of hyperkalemia, particularly in patients with kidney impairment.
What this interaction means in plain words
Finerenone and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Glyburide belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated finerenone metabolism by glyburide.
What to do
Monitor serum potassium when starting or adjusting either drug and adjust the finerenone dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Glyburide?
MediHelp rates the interaction as minor. Finerenone and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide is described as a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This may raise the risk of hyperkalemia, particularly in patients with kidney impairment.
How serious is the interaction between Finerenone and Glyburide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when starting or adjusting either drug and adjust the finerenone dose as needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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