Drug interactions
Finerenone + Hydrochlorothiazide-losartan
Severity: Moderate
Finerenone and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is a weak CYP3A4 inhibitor in vitro, and finerenone is mainly cleared by CYP3A4, so exposure to finerenone may rise slightly. In addition, both losartan and finerenone raise serum potassium, so the combination increases the risk of hyperkalemia, although the thiazide component partly offsets this.
What this interaction means in plain words
Finerenone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive potassium-retaining effects from angiotensin receptor blockade and mineralocorticoid receptor antagonism, plus possible minor CYP3A4 inhibition raising finerenone levels.
What to do
Check serum potassium and renal function at the start of therapy and after dose changes of either drug. Hold or reduce finerenone if potassium rises above the labeled thresholds.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Finerenone and Hydrochlorothiazide-losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Finerenone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan is a weak CYP3A4 inhibitor in vitro, and finerenone is mainly cleared by CYP3A4, so exposure to finerenone may rise slightly. In addition, both losartan and finerenone raise serum potassium, so the combination increases the risk of hyperkalemia, although the thiazide component partly offsets this.
How serious is the interaction between Finerenone and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at the start of therapy and after dose changes of either drug. Hold or reduce finerenone if potassium rises above the labeled thresholds.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
