Drug interactions
Finerenone + Verapamil
Severity: Moderate
Finerenone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil raises finerenone exposure, increasing the risk of hyperkalemia and hypotension. Renal function and baseline potassium add to the risk.
What this interaction means in plain words
Finerenone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition reduces finerenone metabolism.
What to do
Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose according to potassium levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Verapamil?
MediHelp rates the interaction as moderate. Finerenone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil raises finerenone exposure, increasing the risk of hyperkalemia and hypotension. Renal function and baseline potassium add to the risk.
How serious is the interaction between Finerenone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose according to potassium levels.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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