Drug interactions
Finerenone + Zafirlukast
Severity: Moderate
Finerenone and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a weak CYP3A4 inhibitor and may modestly raise finerenone concentrations. Higher finerenone exposure increases the risk of hyperkalemia and renal function changes.
What this interaction means in plain words
Finerenone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast weakly inhibits CYP3A4, reducing the first-pass and systemic metabolism of finerenone.
What to do
Check serum potassium and renal function after starting zafirlukast and during dose changes. Adjust finerenone dosing according to potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Zafirlukast?
MediHelp rates the interaction as moderate. Finerenone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast is a weak CYP3A4 inhibitor and may modestly raise finerenone concentrations. Higher finerenone exposure increases the risk of hyperkalemia and renal function changes.
How serious is the interaction between Finerenone and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function after starting zafirlukast and during dose changes. Adjust finerenone dosing according to potassium results.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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