Drug interactions
Fingolimod + Lomustine
Severity: Major
Fingolimod and Lomustine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine is a myelosuppressive alkylating agent and fingolimod reduces circulating lymphocytes. Combined use increases the risk of serious infections and profound cytopenias.
What this interaction means in plain words
Fingolimod and Lomustine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Lomustine belongs to Oncology.
Why it happens
Additive immunosuppression and bone marrow suppression.
What to do
Avoid combining when possible. If used together, monitor blood counts and closely watch for infection, and consider the lingering effects of one drug when switching to the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Fingolimod with Lomustine?
MediHelp rates the interaction as major. Fingolimod and Lomustine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomustine is a myelosuppressive alkylating agent and fingolimod reduces circulating lymphocytes. Combined use increases the risk of serious infections and profound cytopenias.
How serious is the interaction between Fingolimod and Lomustine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when possible. If used together, monitor blood counts and closely watch for infection, and consider the lingering effects of one drug when switching to the other.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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