Drug interactions
Flecainide + Goserelin
Severity: Moderate
Flecainide and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval. Combined with flecainide, which affects cardiac conduction, the risk of ventricular arrhythmia may increase, especially with other risk factors.
What this interaction means in plain words
Flecainide and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction; testosterone suppression by goserelin is associated with QT prolongation.
What to do
Obtain a baseline ECG and monitor periodically, and correct potassium and magnesium abnormalities. Reassess the antiarrhythmic choice if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Flecainide with Goserelin?
MediHelp rates the interaction as moderate. Flecainide and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval. Combined with flecainide, which affects cardiac conduction, the risk of ventricular arrhythmia may increase, especially with other risk factors.
How serious is the interaction between Flecainide and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, and correct potassium and magnesium abnormalities. Reassess the antiarrhythmic choice if QTc becomes markedly prolonged.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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