Drug interactions
Flecainide + Indacaterol
Severity: Moderate
Flecainide and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide slows cardiac conduction and is proarrhythmic, especially in structural heart disease, and indacaterol can add tachycardia and hypokalemia. Hypokalemia can increase flecainide toxicity, raising the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Flecainide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects, with beta-2 agonist induced hypokalemia increasing susceptibility.
What to do
Monitor ECG and serum potassium and correct deficits before and during therapy. Reassess the combination if QRS widening or arrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Indacaterol?
MediHelp rates the interaction as moderate. Flecainide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flecainide slows cardiac conduction and is proarrhythmic, especially in structural heart disease, and indacaterol can add tachycardia and hypokalemia. Hypokalemia can increase flecainide toxicity, raising the risk of serious ventricular arrhythmia.
How serious is the interaction between Flecainide and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and correct deficits before and during therapy. Reassess the combination if QRS widening or arrhythmia occurs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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