Drug interactions
Flecainide + Ozanimod
Severity: Moderate
Flecainide and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause heart rate slowing and atrioventricular conduction delay, particularly at initiation. Flecainide slows conduction, so the combination may increase the risk of bradyarrhythmia or proarrhythmia.
What this interaction means in plain words
Flecainide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on heart rate and cardiac conduction.
What to do
Obtain a baseline ECG before starting ozanimod and seek cardiology advice. Monitor heart rate and conduction during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Flecainide with Ozanimod?
MediHelp rates the interaction as moderate. Flecainide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause heart rate slowing and atrioventricular conduction delay, particularly at initiation. Flecainide slows conduction, so the combination may increase the risk of bradyarrhythmia or proarrhythmia.
How serious is the interaction between Flecainide and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and seek cardiology advice. Monitor heart rate and conduction during initiation.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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