Drug interactions
Flecainide + Panobinostat
Severity: Major
Flecainide and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and has been associated with ECG changes and arrhythmias. Adding flecainide, which affects cardiac conduction and can be proarrhythmic, further increases the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Flecainide and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Panobinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Avoid the combination and use an alternative rhythm-control strategy. If it cannot be avoided, obtain baseline and serial ECGs and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Flecainide with Panobinostat?
MediHelp rates the interaction as major. Flecainide and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and has been associated with ECG changes and arrhythmias. Adding flecainide, which affects cardiac conduction and can be proarrhythmic, further increases the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Flecainide and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative rhythm-control strategy. If it cannot be avoided, obtain baseline and serial ECGs and keep potassium and magnesium within normal range.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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