Drug interactions
Flecainide + Risperidone
Severity: Moderate
Flecainide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone has a modest QT-prolonging effect and is a CYP2D6 substrate, while flecainide is also a CYP2D6 substrate with proarrhythmic potential. Combined use may increase the risk of ventricular arrhythmia, especially in patients with heart disease.
What this interaction means in plain words
Flecainide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction, with possible competition for CYP2D6 metabolism.
What to do
Monitor ECG at baseline and after dose changes and correct electrolyte abnormalities. Watch for signs of flecainide or risperidone excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Flecainide with Risperidone?
MediHelp rates the interaction as moderate. Flecainide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone has a modest QT-prolonging effect and is a CYP2D6 substrate, while flecainide is also a CYP2D6 substrate with proarrhythmic potential. Combined use may increase the risk of ventricular arrhythmia, especially in patients with heart disease.
How serious is the interaction between Flecainide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and after dose changes and correct electrolyte abnormalities. Watch for signs of flecainide or risperidone excess.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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