Drug interactions
Flecainide + Trazodone
Severity: Moderate
Flecainide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QT interval and cause arrhythmias, which may add to the proarrhythmic potential of flecainide. Trazodone is also a CYP2D6 substrate, and flecainide may modestly affect its metabolism.
What this interaction means in plain words
Flecainide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and conduction effects.
What to do
Obtain a baseline ECG, monitor QT and QRS, and keep electrolytes normal; consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Flecainide with Trazodone?
MediHelp rates the interaction as moderate. Flecainide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QT interval and cause arrhythmias, which may add to the proarrhythmic potential of flecainide. Trazodone is also a CYP2D6 substrate, and flecainide may modestly affect its metabolism.
How serious is the interaction between Flecainide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, monitor QT and QRS, and keep electrolytes normal; consider an alternative antidepressant in high-risk patients.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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