Drug interactions
Flibanserin + Fluvoxamine
Severity: Major
Flibanserin and Fluvoxamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a strong CYP2C19 inhibitor and also inhibits CYP3A4 to a lesser degree, and may considerably raise flibanserin exposure. This increases the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flibanserin belongs to Genitourinary; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 (and CYP3A4) decreases flibanserin metabolism and raises plasma concentrations.
What to do
Avoid combining or use with great caution; flibanserin labeling advises against use with strong CYP2C19 inhibitors. Monitor for hypotension, syncope and sedation if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Flibanserin with Fluvoxamine?
MediHelp rates the interaction as major. Flibanserin and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine is a strong CYP2C19 inhibitor and also inhibits CYP3A4 to a lesser degree, and may considerably raise flibanserin exposure. This increases the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining or use with great caution; flibanserin labeling advises against use with strong CYP2C19 inhibitors. Monitor for hypotension, syncope and sedation if unavoidable.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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