Drug interactions
Flibanserin + Hydroxyzine
Severity: Moderate
Flibanserin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine with anxiolytic effects, and with flibanserin it can increase drowsiness and impair alertness.
What this interaction means in plain words
Flibanserin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Hydroxyzine belongs to Respiratory.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel about sedation and avoid driving; reduce the hydroxyzine dose or choose a non-sedating alternative if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Flibanserin with Hydroxyzine?
MediHelp rates the interaction as moderate. Flibanserin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine with anxiolytic effects, and with flibanserin it can increase drowsiness and impair alertness.
How serious is the interaction between Flibanserin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and avoid driving; reduce the hydroxyzine dose or choose a non-sedating alternative if drowsiness occurs.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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