Drug interactions
Flibanserin + Lonafarnib
Severity: Contraindicated
Flibanserin and Lonafarnib: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib inhibits CYP3A4 strongly and may raise flibanserin exposure. This increases risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flibanserin belongs to Genitourinary; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits CYP3A4 (and CYP2C19), reducing flibanserin clearance.
What to do
Avoid concomitant use. Choose alternatives to one agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Flibanserin with Lonafarnib?
MediHelp rates the interaction as contraindicated. Flibanserin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib inhibits CYP3A4 strongly and may raise flibanserin exposure. This increases risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Choose alternatives to one agent.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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