Drug interactions
Flibanserin + Mefloquine
Severity: Minor
Flibanserin and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine is not an established CYP3A4 inhibitor, so any rise in flibanserin exposure is speculative. Flibanserin levels depend heavily on CYP3A4, and higher exposure could worsen hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by mefloquine is poorly established.
What to do
No routine adjustment is needed. Counsel the patient about dizziness and syncope, and review the regimen if several weak CYP3A4 inhibitors are being taken together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Mefloquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Flibanserin with Mefloquine?
MediHelp rates the interaction as minor. Flibanserin and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine is not an established CYP3A4 inhibitor, so any rise in flibanserin exposure is speculative. Flibanserin levels depend heavily on CYP3A4, and higher exposure could worsen hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Counsel the patient about dizziness and syncope, and review the regimen if several weak CYP3A4 inhibitors are being taken together.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
