Drug interactions
Flibanserin + Omeprazole
Severity: Moderate
Flibanserin and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19 and weakly CYP3A4, both involved in flibanserin clearance. Higher flibanserin exposure raises the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19 and CYP3A4 metabolism of flibanserin.
What to do
Monitor for dizziness, hypotension and sedation, particularly after dosing at bedtime. Counsel patients and avoid additional CYP3A4 inhibitors or alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Omeprazole?
MediHelp rates the interaction as moderate. Flibanserin and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole inhibits CYP2C19 and weakly CYP3A4, both involved in flibanserin clearance. Higher flibanserin exposure raises the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation, particularly after dosing at bedtime. Counsel patients and avoid additional CYP3A4 inhibitors or alcohol.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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