Drug interactions
Flibanserin + Paliperidone
Severity: Moderate
Flibanserin and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and orthostatic hypotension, so combined use may increase dizziness and syncope. A serotonergic or dopaminergic interaction is theoretical.
What this interaction means in plain words
Flibanserin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension; pharmacodynamic.
What to do
Monitor for sedation and orthostatic hypotension. Counsel the patient about dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Flibanserin with Paliperidone?
MediHelp rates the interaction as moderate. Flibanserin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and orthostatic hypotension, so combined use may increase dizziness and syncope. A serotonergic or dopaminergic interaction is theoretical.
How serious is the interaction between Flibanserin and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension. Counsel the patient about dizziness.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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