Drug interactions
Flibanserin + Perphenazine
Severity: Moderate
Flibanserin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and can lower blood pressure, so combined use may increase drowsiness and syncope. Perphenazine is metabolized mainly by CYP2D6 and is not a notable CYP3A4 inhibitor.
What this interaction means in plain words
Flibanserin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension.
What to do
Monitor for sedation and orthostatic hypotension. Counsel the patient about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Flibanserin with Perphenazine?
MediHelp rates the interaction as moderate. Flibanserin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and can lower blood pressure, so combined use may increase drowsiness and syncope. Perphenazine is metabolized mainly by CYP2D6 and is not a notable CYP3A4 inhibitor.
How serious is the interaction between Flibanserin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension. Counsel the patient about driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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