Drug interactions
Flibanserin + Rimegepant
Severity: Moderate
Flibanserin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits intestinal P-glycoprotein and may increase rimegepant exposure. The clinical significance is uncertain but could increase rimegepant adverse effects.
What this interaction means in plain words
Flibanserin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Rimegepant belongs to Central Nervous System.
Why it happens
Flibanserin inhibits P-glycoprotein efflux, increasing rimegepant absorption.
What to do
Avoid a second rimegepant dose within 48 hours when coadministered with a P-gp inhibitor. Monitor for rimegepant adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Flibanserin with Rimegepant?
MediHelp rates the interaction as moderate. Flibanserin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits intestinal P-glycoprotein and may increase rimegepant exposure. The clinical significance is uncertain but could increase rimegepant adverse effects.
How serious is the interaction between Flibanserin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when coadministered with a P-gp inhibitor. Monitor for rimegepant adverse effects.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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