Drug interactions
Flibanserin + Sirolimus
Severity: Moderate
Flibanserin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits P-glycoprotein and may raise sirolimus levels, which matters because sirolimus has a narrow therapeutic index. Sirolimus is a CYP3A4 and P-gp substrate, so toxicity such as hyperlipidemia, cytopenias and immunosuppression may increase.
What this interaction means in plain words
Flibanserin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Sirolimus belongs to Miscellaneous.
Why it happens
Flibanserin inhibits intestinal P-glycoprotein, increasing sirolimus absorption.
What to do
Monitor sirolimus trough concentrations after starting or stopping flibanserin and adjust the dose accordingly. Watch for flibanserin-related sedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Flibanserin with Sirolimus?
MediHelp rates the interaction as moderate. Flibanserin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits P-glycoprotein and may raise sirolimus levels, which matters because sirolimus has a narrow therapeutic index. Sirolimus is a CYP3A4 and P-gp substrate, so toxicity such as hyperlipidemia, cytopenias and immunosuppression may increase.
How serious is the interaction between Flibanserin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations after starting or stopping flibanserin and adjust the dose accordingly. Watch for flibanserin-related sedation and hypotension.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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