Drug interactions
Fluconazole + Histrelin
Severity: Moderate
Fluconazole and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, produces androgen deprivation that can prolong the QT interval, and fluconazole has independent QT-prolonging potential. Combined use may raise the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Fluconazole and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation from androgen deprivation therapy and fluconazole.
What to do
Review the baseline QTc and correct electrolyte abnormalities. Monitor the ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Fluconazole with Histrelin?
MediHelp rates the interaction as moderate. Fluconazole and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, produces androgen deprivation that can prolong the QT interval, and fluconazole has independent QT-prolonging potential. Combined use may raise the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Fluconazole and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct electrolyte abnormalities. Monitor the ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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