Drug interactions
Fluconazole + Hydrochlorothiazide-losartan
Severity: Moderate
Fluconazole and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its active metabolite E-3174. This can raise losartan levels and reduce the active metabolite, with an uncertain effect on blood pressure.
What this interaction means in plain words
Fluconazole and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9 and CYP3A4-mediated conversion of losartan to E-3174.
What to do
Monitor blood pressure when fluconazole is started or stopped. Adjust the losartan dose if the antihypertensive response changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Fluconazole and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its active metabolite E-3174. This can raise losartan levels and reduce the active metabolite, with an uncertain effect on blood pressure.
How serious is the interaction between Fluconazole and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when fluconazole is started or stopped. Adjust the losartan dose if the antihypertensive response changes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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