Drug interactions
Fluconazole + Imatinib
Severity: Moderate
Fluconazole and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise imatinib plasma levels because imatinib is primarily metabolized by CYP3A4. Higher exposure could increase fluid retention, myelosuppression and hepatotoxicity.
What this interaction means in plain words
Fluconazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Imatinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of imatinib.
What to do
Monitor blood counts, liver tests and fluid status. Reduce the imatinib dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluconazole with Imatinib?
MediHelp rates the interaction as moderate. Fluconazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may raise imatinib plasma levels because imatinib is primarily metabolized by CYP3A4. Higher exposure could increase fluid retention, myelosuppression and hepatotoxicity.
How serious is the interaction between Fluconazole and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests and fluid status. Reduce the imatinib dose if toxicity appears.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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