Drug interactions
Fluconazole + Ipratropium-salbutamol
Severity: Moderate
Fluconazole and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval and has been linked to torsades de pointes, especially at higher doses or with electrolyte disturbances. Salbutamol may add to this through tachycardia and lowered potassium. The risk is mainly relevant with high-dose or frequent salbutamol use.
What this interaction means in plain words
Fluconazole and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT-prolonging potential, with beta-agonist-induced hypokalemia increasing susceptibility.
What to do
Check potassium and magnesium and correct deficits; obtain an ECG if the patient has other QT risk factors. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Fluconazole and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval and has been linked to torsades de pointes, especially at higher doses or with electrolyte disturbances. Salbutamol may add to this through tachycardia and lowered potassium. The risk is mainly relevant with high-dose or frequent salbutamol use.
How serious is the interaction between Fluconazole and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits; obtain an ECG if the patient has other QT risk factors. Avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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