Drug interactions
Fluconazole + Isavuconazonium
Severity: Moderate
Fluconazole and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate. Fluconazole may raise isavuconazole concentrations, although the effect of a moderate inhibitor is expected to be limited. Combining two azole antifungals is rarely needed and may increase hepatic and QT-shortening effects.
What this interaction means in plain words
Fluconazole and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Isavuconazonium belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, which can reduce isavuconazole clearance.
What to do
Avoid combining two azoles unless specifically intended; if used together, monitor liver enzymes and the clinical response and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Fluconazole with Isavuconazonium?
MediHelp rates the interaction as moderate. Fluconazole and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate. Fluconazole may raise isavuconazole concentrations, although the effect of a moderate inhibitor is expected to be limited. Combining two azole antifungals is rarely needed and may increase hepatic and QT-shortening effects.
How serious is the interaction between Fluconazole and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two azoles unless specifically intended; if used together, monitor liver enzymes and the clinical response and adverse effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
