Drug interactions
Fluconazole + Memantine-donepezil
Severity: Moderate
Fluconazole and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and fluconazole can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Fluconazole may also modestly raise donepezil exposure through CYP3A4 inhibition.
What this interaction means in plain words
Fluconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus fluconazole inhibition of CYP3A4 (and CYP2D6 to a lesser degree) metabolism of donepezil.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and for cholinergic effects such as bradycardia, and stop if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Memantine-donepezil?
MediHelp rates the interaction as moderate. Fluconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and fluconazole can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Fluconazole may also modestly raise donepezil exposure through CYP3A4 inhibition.
How serious is the interaction between Fluconazole and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and for cholinergic effects such as bradycardia, and stop if the QTc becomes markedly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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