Drug interactions
Fluconazole + Naldemedine
Severity: Moderate
Fluconazole and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is metabolized primarily by CYP3A4, and moderate CYP3A4 inhibitors such as fluconazole can increase its plasma concentrations. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
What this interaction means in plain words
Fluconazole and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Fluconazole inhibits CYP3A4, reducing naldemedine clearance.
What to do
No dose adjustment is required; monitor for abdominal pain, diarrhea, and signs of opioid withdrawal. Reassess if symptoms become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Fluconazole with Naldemedine?
MediHelp rates the interaction as moderate. Fluconazole and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naldemedine is metabolized primarily by CYP3A4, and moderate CYP3A4 inhibitors such as fluconazole can increase its plasma concentrations. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
How serious is the interaction between Fluconazole and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for abdominal pain, diarrhea, and signs of opioid withdrawal. Reassess if symptoms become troublesome.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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