Drug interactions
Fluconazole + Nicardipine
Severity: Moderate
Fluconazole and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is metabolized by CYP3A4 and other CYPs, so fluconazole may increase its concentrations. This can cause excessive hypotension, flushing, headache, and peripheral edema.
What this interaction means in plain words
Fluconazole and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Nicardipine belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP3A4 and CYP2C9, reducing nicardipine clearance.
What to do
Monitor blood pressure and heart rate when starting fluconazole. Lower the nicardipine dose if hypotension or adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Fluconazole with Nicardipine?
MediHelp rates the interaction as moderate. Fluconazole and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is metabolized by CYP3A4 and other CYPs, so fluconazole may increase its concentrations. This can cause excessive hypotension, flushing, headache, and peripheral edema.
How serious is the interaction between Fluconazole and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting fluconazole. Lower the nicardipine dose if hypotension or adverse effects appear.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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