Drug interactions
Fluconazole + Nimodipine
Severity: Moderate
Fluconazole and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise nimodipine levels, increasing the risk of hypotension and reduced cerebral perfusion pressure, which is important in subarachnoid hemorrhage.
What this interaction means in plain words
Fluconazole and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Nimodipine belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP3A4-mediated first-pass and hepatic metabolism of nimodipine.
What to do
Monitor blood pressure closely and split the nimodipine dosing or reduce the dose if hypotension develops. Consider an alternative antifungal if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Fluconazole with Nimodipine?
MediHelp rates the interaction as moderate. Fluconazole and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may raise nimodipine levels, increasing the risk of hypotension and reduced cerebral perfusion pressure, which is important in subarachnoid hemorrhage.
How serious is the interaction between Fluconazole and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and split the nimodipine dosing or reduce the dose if hypotension develops. Consider an alternative antifungal if possible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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