Drug interactions
Fluconazole + Paclitaxel
Severity: Moderate
Fluconazole and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase paclitaxel exposure, since paclitaxel is cleared by CYP2C8 and CYP3A4. This could worsen neutropenia and neuropathy, although the effect of fluconazole is likely modest.
What this interaction means in plain words
Fluconazole and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Paclitaxel belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of paclitaxel.
What to do
Monitor blood counts and neurotoxicity during co-therapy. Adjust the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Fluconazole with Paclitaxel?
MediHelp rates the interaction as moderate. Fluconazole and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase paclitaxel exposure, since paclitaxel is cleared by CYP2C8 and CYP3A4. This could worsen neutropenia and neuropathy, although the effect of fluconazole is likely modest.
How serious is the interaction between Fluconazole and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity during co-therapy. Adjust the paclitaxel dose if toxicity develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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