Drug interactions
Fluconazole + Pemigatinib
Severity: Major
Fluconazole and Pemigatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase pemigatinib exposure, potentially worsening hyperphosphatemia, ocular toxicity and other adverse effects. Pemigatinib is metabolized mainly by CYP3A4.
What this interaction means in plain words
Fluconazole and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Pemigatinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of pemigatinib.
What to do
Avoid if possible; if needed, reduce pemigatinib dose per labeling (for example from 13.5 mg to 9 mg, or 9 mg to 4.5 mg) and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Fluconazole with Pemigatinib?
MediHelp rates the interaction as major. Fluconazole and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can increase pemigatinib exposure, potentially worsening hyperphosphatemia, ocular toxicity and other adverse effects. Pemigatinib is metabolized mainly by CYP3A4.
How serious is the interaction between Fluconazole and Pemigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, reduce pemigatinib dose per labeling (for example from 13.5 mg to 9 mg, or 9 mg to 4.5 mg) and monitor for toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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