Drug interactions
Fluconazole + Pexidartinib
Severity: Major
Fluconazole and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise pexidartinib exposure, increasing the risk of hepatotoxicity, which is a boxed warning for pexidartinib. Pexidartinib is cleared partly by CYP3A4.
What this interaction means in plain words
Fluconazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Pexidartinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of pexidartinib.
What to do
Avoid if possible; if unavoidable, reduce pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Fluconazole with Pexidartinib?
MediHelp rates the interaction as major. Fluconazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole may raise pexidartinib exposure, increasing the risk of hepatotoxicity, which is a boxed warning for pexidartinib. Pexidartinib is cleared partly by CYP3A4.
How serious is the interaction between Fluconazole and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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