Drug interactions
Fluconazole + Prednisone
Severity: Moderate
Fluconazole and Prednisone: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole, a CYP3A4 inhibitor, can modestly increase exposure to prednisolone, the active form of prednisone. This may enhance corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression, especially at higher fluconazole doses.
What this interaction means in plain words
Fluconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Prednisone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4, reducing hepatic clearance of prednisolone.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia and edema, and consider reducing the prednisone dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Fluconazole - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Prednisone?
MediHelp rates the interaction as moderate. Fluconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole, a CYP3A4 inhibitor, can modestly increase exposure to prednisolone, the active form of prednisone. This may enhance corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression, especially at higher fluconazole doses.
How serious is the interaction between Fluconazole and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia and edema, and consider reducing the prednisone dose if they appear.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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