Drug interactions
Fluconazole + Ritonavir
Severity: Minor
Fluconazole and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may modestly raise ritonavir concentrations. Ritonavir's own effects on CYP3A4 mean fluconazole levels change little, and the combination is usually tolerated.
What this interaction means in plain words
Fluconazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Ritonavir belongs to Anti Virals.
Why it happens
Fluconazole inhibits CYP3A4, slightly reducing ritonavir metabolism.
What to do
No routine dose adjustment is needed. Monitor for ritonavir adverse effects such as gastrointestinal upset and hepatotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Fluconazole with Ritonavir?
MediHelp rates the interaction as minor. Fluconazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may modestly raise ritonavir concentrations. Ritonavir's own effects on CYP3A4 mean fluconazole levels change little, and the combination is usually tolerated.
How serious is the interaction between Fluconazole and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for ritonavir adverse effects such as gastrointestinal upset and hepatotoxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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